大鼠灌胃川芎、当归及其复方后阿魏酸的药代动力学

Pharmacokinetics of Ferric Acid in Rat after Oral Administration of Radix Angelica Sinensis,Rhizoma Chuanxiong and Their Compound Preparations

目的 :研究大鼠灌胃当归、川芎及其复方 (亦称佛手散 )后 ,阿魏酸的药代动力学特性。方法 :大鼠灌胃当归、川芎和佛手散煎液后 ,用HPLC法测定血浆中阿魏酸浓度 ,估算相应的药代动力学参数。结果 :大鼠灌胃当归、川芎和佛手散煎液后 5min ,血浆中阿魏酸浓度达峰值。 3种煎液的阿魏酸半衰期相近 (P >0 0 5 ) ,分别约为 88 5± 2 3 1,70 9± 14 3和 6 7 9± 2 2 4min ,但cmax和AUC存在显著差异 ,剂量校正后差异更显著。川芎组血浆中阿魏酸浓度和AUC最高 ,而佛手散组血浆中阿魏酸浓度和AUC最低。剂量校正后的AUC180 分别为4 375 8± 16 6 3 7,986 6 5± 2 6 89 5和 2 0 84 1± 4 0 5 9ng·min/ml。cmax分别为 10 8 7± 33 4 ,317± 181 3和 39 5± 17 9ng/ml。结论 :阿魏酸在当归、川芎及其复方佛手散中的吸收程度不同。

AIM:To study pharmacokinetics of ferric acid(FA) in rat after oral administration of Radix Angelica Sinensis, Rhizoma Chuanxiong and their compound proparations (fushousan). METHOD: Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan were given to rats by ig, concentrations of FA in plasma were determined using HPLC method and main pharmacokinetic parameters were estimated. RESULT:Peak concentration of FA in rat plasma occurred at 5 min after ig Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan. Half-lives were 88.5±23.1,70.9±14.3 and 67.9±22.4 min, respectively. There existed significant( P <0.01) differences in plasma concentration and AUC of FA among Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan. The values of normalized AUC _ 180 by dose of FA were 4375.8±1663.7, 9866.5±2689.5 and 2084.1±405.9 ng·min/ml respectively. The values of normalized c _ max by dose of FA were 108.7±33.4, 317±181.3 and 39.5±17.9 ng/ml. CONCLUSION:There existed large differences in absorption content of FA in rat after ig Radix Angelica Sinensis, Rhizoma Chuanxiong and fushousan.