卡维地洛和培哚普利对急性心肌梗死后心功能改善的影响

Effect of Carvedilol and Perindopril on cardiac function of patients with heart failure after acute myocardial infarction

目的 :观测卡维地洛和培哚普利对急性心肌梗死后心功能的影响。方法 :急性心梗后心功能不全住院患者 6 2例。随机分成 2组先分别给予卡维地洛及培哚普利治疗 3月 ,然后再联合治疗 3月后复查超声心动图测定左室功能。结果 :1单用卡维地洛或培哚普利均可显著降低左室收缩末期容积 (L VESV ) ,左室射血分数 (L VEF)明显增加 ,左室充盈早期血流传播速度 (L VFPS)明显加快。2两药联用后 L VESV,L VEF及 L VFPS较单用药组有显著性变化。结论

AIM: To observe the effect of Carvedilol and Perindopril on cardiac function of patients with heart failure after acute myocardial infarction. METHODS: 62 inpatients with heart failure after acute myocardial infarction were randomized into Carvedilol group and Perindopril group in the first 3 months, and then treated with the combination of Carvedilol and Perindopril. The left ventricular function of these patients was measured by echocardiography at the beginning and at the end of the test respectively. RESULTS:①Carvedilol or Perindopril alone could reduce the left ventricular end systole volume(LVESV) and increase the left ventricular ejection fraction(LVEF) significantly, and the left ventricular filling propagation slope(LVFPS) becomes faster. ②The changes of LVESV, LVEF and LVFPS were more significant when patients were treated with the combination of the two drugs than with either alone of them. CONCLUSION: There is a significant effect of Carvedilol and Perindopril on cardiac function of patients with acute myocardial infarction.