血清总胆红素与冠状动脉狭窄的相关性

Association of total serum bilirubin concentration with coronary atherogenesis of coronary artery disease

目的 :探讨血清总胆红素水平与冠状动脉狭窄程度的关系。方法 :符合条件的冠状动脉造影患者 14 6例 ,根据狭窄程度分成 3组。正常组 :6 0例 ,血管狭窄程度 <10 %。轻度狭窄组 :16例 ,狭窄程度 10 %～ 4 9%。重度狭窄组 :70例 ,至少一支血管狭窄 >5 0 %。采空腹肘静脉血测定血清总胆红素水平并进行比较。结果 :正常组血清总胆红素显著高于轻度狭窄组及重度狭窄组 (P<0 .0 5 ) ,轻度狭窄组与重度狭窄组之间血清总胆红素水平差异无显著性。重度狭窄组中单支病变与两支病变、单支病变与三支病变的总胆红素水平有高度显著差异 (P<0 .0 1)。血清总胆红素水平越低者 ,冠状动脉狭窄程度越重。结论 :血清总胆红素水平与冠状动脉狭窄程度呈负相关。

AIM: To explore the association of low serum total bilirubin with increased risk of atherogenesis. METHODS: 146 patients who had been done selective coronary angiography were divided into 3 groups according to the coronary atherogenesis.(A)normal,all vessels stenosis 0～10%, n =60. (B) light coronary atherogenesis, at least one vessel stenosis 10%～49%, n =16. (C)Severe coronary atberogenesis, at least one vessel stenosis> 50%, n =70.Their serum total bilirubin concentrations were measured and compared. RESULTS: The serum bilirubin concentration of group A was significant higher than that of group B and group C( P <0.05).Whereas there were no statistical difference between group B and group C. There were significant statistical difference between Ⅰ and Ⅱ, Ⅰ and Ⅲ in group C ( P <0.01). Chi-square test revealed a significant inverse association between serum total bilirubin concentration and themorbidity of CAD. Those with lower bilirubin levels showed a more severe of coronary atherogenesis. CONCLUSION: The serum total bilirubin had negative correlation with coronary atherogenesis.