速效心痛滴丸的成型工艺设计研究

Study on preparation process for Suxiaoxintong Dropping Pills

目的 :确立速效心痛滴丸 (牡丹皮 ,川芎 ,冰片 )的最佳成型工艺。方法 :采用正交试验法 ,从基质 ,冷却剂的种类 ,提取物与基质的用量配比等方面进行优选。结果 :根据实验确定的最优工艺制成的滴丸 ,符合《中国药典》(2 0 0 0年版 )的规定。结论 :此工艺适合大生产。

Objective: To establish the optimum preparation process for Suxiaoxintong Dropping Pills (Cortex moutan, Rhizoma Chuanxiong, Borneolum Syntheticum). Methods: The preparation conditions, such as the different kinds of primary substance, cooling agent, the proportion between the extracts and primary substance etc. were studied with L 18 (3 7) orthogonal design. Results: Six batches of the products prepared with the process on the experimental result were conformed to the standard of the Chinese pharmacopoeia. Conclusion: It has been proved that the process is available.