麝香保心丸与消心痛单次给药对缓解稳定性心绞痛的疗效比较

Comparision the effect on relievling stable angina between Shexiang Baoxin Pill and Isosorbide Dinitrate by singly dosing

目的 :探讨麝香保心丸与消心痛对缓解稳定性心绞痛的临床疗效 ,并且在缓解心绞痛前后对患者血压、脉压、心率的影响。方法 :将 10 0例确诊为稳定性心绞痛的患者 ,随机、双盲分为治疗组 (5 5例 )和对照组 (45例 )。在心绞痛发作时按内科常规处理的同时分别给予麝香保心丸 8～ 10粒与消心痛 10mg～ 2 0mg舌下含服。 结果 :麝香保心丸组和消心痛组均可显著缓解心绞痛 ,两组间无显著性差异 (P >0 .0 5 ) ,且麝香保心丸在缓解心绞痛前后 ,患者的血压、脉压、心率无显著差异 (P >0 .0 5 )。结论 :麝香保心丸和消心痛均可显著缓解心绞痛症状 ,但使用麝香保心丸更安全 。

Objective: To test and verify the clinical effect of Shexiang Baoxin Pill (SXBXP) and Isosorbide Dinitrate in reducing the clinical symptom of stable angina pectoris and their effects on the blood pressure, pulse pressure and heart rate of patients before and after reducing the clinical symptom of stable angina pectoris. Methods: One hundred patients of stable angina pectoris were randomly and blindly assigned to the study group (55 cases) and the control group (45 cases). Eight to ten pills of SXBXP and 10mg to 20mg Isosorbide Dinitrate were given to each case of the two groups and sucked under the tongue while the patients were treated by the routine treatment. Results: Both SXBXP and Isosorbide Dinitrate could significantly reduce the clinical symptom of stable angina pectoris without any remarkable difference ( P >0.05) between two groups. SXBXP shows no remarkable difference in the blood pressure, pulse pressure and heart rate of patients before and after reducing the clinical symptom of stable angina pectoris ( P >0.05). Conclusion: Both SXBXP and Isosorbide Dinitrate can significantly reduce the symptom of stable angina pectoris, but SXBXP is safer and has fewer side effects.