升白合剂治疗化疗后白细胞减少症的临床及实验研究

Clinical and Experimental Studies on the Efficacy of WBC - raising Mixture on Post - chemotherapy Leukopenia

为观察升白合剂对化疗后白细胞减少症的临床疗效,将96例患者随机分为两组各48例,治疗组在化疗的同时服用升白合剂,对照组服用利血生、鲨肝醇,观察治疗前后白细胞、免疫球蛋白及一般状况的变化,结果治疗组升白细胞作用、提高抗体免疫功能及临床有效率均优于对照组(P<0.05)。实验研究观察对试验性小白鼠白细胞减少症的影响,观察组每天每只小鼠胃饲升白合剂,对照组胃饲生理盐水,两组均同时腹腔注射环磷酰胺,每天1次,连续7 d,观察小鼠周围血中中性粒细胞变化及动物反应,结果显示观察组动物周围血中性粒细胞明显升高,与治疗前比较具有显著性差异(P<0.05),与对照组比较具有显著性差异(P<0.05);用药7 d后观察组动物活动增加,耳廓红润,无一例死亡;对照组动物却出现懒动、耳廓苍白,其中7例死亡。

In order to observe the clinical efficacy of this mixture on post - chemotherapy leukopenia, 96 patients were divided randomly into treatment group and control group, the former given this mixture for oral administration while they had chemotherapy, and the latter leucogen, and batyl alcohol. The WBC, Ig, and general condition of the patients were observed. It turned out that better efficacy was found in the former in terms of raised WBC, improved immunity, and effective rate, when compared with those in the latter (P<0.05). Mouse were used for experimental studies. Those in the observation group were raised daily with this mixture, while the control group with normal saline. Meanwhile both groups were given intra - abdominal injections of cyclophosphamide once daily continuously for seven days to observe the variation of peripheral blood neutrophils as well as the reactions of the animals. It turned out that the peripheral blood neutrophils in the observation group rose markedly, with significant difference when compared with the figure pre- treatment (P<0.05) as well as with those in the control group (P<0.05). Seven days after the medication, animals in the former group had increased movements, reddened auricles, and remained alive. While those in the control group were reluctant to move around with pale auricles, and seven of them died.