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XRCC1与DNA修复 被引量：7

XRCC1 and DNA repair
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摘要 XRCC1是影响细胞对电离辐射的敏感性的第一个哺乳类动物基因。XRCC1通过与PARP、DNA连接酶Ⅲ和DNA多聚酶β等作用,在DNA损伤时单链断裂修复中起重要作用。现就XRCC1的分子生物学特性及XRCC1在DNA修复可能机制进行综述。 XRCC1 is the first cloned mammalian gene involved in correcting DNA damage from X-rays or ionizing radiation.XRCC1 encodes a protein that functions in repair of single strand breaks in DNA,presumably through its interactins with poly(ADP-ribose)Polymerase(PARP)and DNA ligase Ⅲ and DNA Polymerase β in base excision repair pathway.
作者 蒋祝昌
机构地区 广西桂林医学院附属医院神经内科
出处 《国外医学（生物医学工程分册）》 2003年第5期234-237,共4页 Foreign Medical Sciences(Biomedical Engineering Fascicle)
关键词 XRCC1 DNA 修复 X-ray repair cross complementing l(XRCC1) DNA repair
分类号 Q523 [生物学—生物化学]
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参考文献19

  • 1Masson M,Niedergang C,Schreiber V,et al. XRCC1 is specifically associated with poly(ADP-fibose) polymerase and negatively regulates its activity follying DNA damage [J]. Mol Cell Biol, 1998,18(6) : 3563-3571.
  • 2Caldecott KW,Tuker JD,Stanker LH,et al. Characterization of the XRCC1-DNA ligase Ⅲ complex in vitro and its absence from mutant hamster cells[J]. Nucleic Acids Res, 1995,23(23) :4836-4843.
  • 3Taylor RM,Moore DJ,Whitehouse J,et al. A cell specific requirement for the XRCC1 BRCT Ⅱ domain during mammalian DNA strand break repair[J]. Mol Cell Biol.2000,20(2) : 735-740.
  • 4Nash RA,Caldecott KW,Barnes DE,et al. XRCC1 protein interacts with one of two distinct forms of DNA ligase Ⅲ [J]. Biochemistry, 1997,36(17) :5207-5211.
  • 5Dulic A,Bates PA,Zhang X,et al. BRCT domain interactions in the heterodimeric DNA repair protein XRCC1DNA ligase Ⅲ [J]. Biochemistry,2001,40(20) :5906-5913.
  • 6Cappelli E,Taylor R,Cevasco M,et al. Involvement of XRCC1 and DNA ligase mgene products in DNA base excision repair[J]. J Biol Chem, 1997,272(38):23970-23975.
  • 7Whitehouse CJ,Taylir RM,Thistlethwaite A,et al. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA singlestrand break repair[J]. Cell, 2001,104(1) : 107-117.
  • 8Thompson LH,Brookman KW,Jones NJ,et al. Molecular cloning of the human XRCC1 gene,which corrects defective DNA strand break repair and sister chromatidexchange[J]. Mol Cell Biol, 1990,10(12) :6160-6171.
  • 9Caldecott KW,Aoufouchi S,Johnsen P,et al. XRCC1 polypeptide interacts with DNA polymemse beta and possibly poly(ADP-ribose) polymerase,and DNA ligase Ⅲ is a novel molecular 'nick-sensor' in vitro[J]. Nucleic Acids Res, 1996,24 (22) : 4387-4394.
  • 10Lamerdin JE,Montgomery MA,Stilwagen SA,et al. Genomic seqence comparison of the human and mouse XRCC1 DNA repair gene regions[J]. Genomics,1995,25(2) :547-554.

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国外医学（生物医学工程分册）
2003年 第5期

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