核转录因子κB与前列腺癌

NF-κB and Prostatic Adenocarcinoma

核转录因子κB(nuclearfactorofkappaB ,NF κB)是一种多极性核转录因子 ,参与调控多种与免疫反应、凋亡、炎症、肿瘤形成和转移有关的基因表达。近年来 ,NF κB在肿瘤发生、耐药、转移中的作用及其机制逐渐成为医学研究的热点。本文主要综述了NF κB的结构、生物学功能及其抗凋亡诱发肿瘤的机制 ,NF κB调控的前列腺癌相关基因的表达和调控 ,NF κB参与前列腺癌浸润与转移的机制及其在前列腺癌基因治疗中的可能策略等。

Nuclear factor of kappa B(NF κB) is a multipolar nuclear transcription factor, and adjusts many gene expressions concerned with immunization, apoptosis, inflammation, neoplasia and metastasis. Recently, NF κB has become a kind of hot spot in the studies of neoplasia, infiltration, metastasis and drug resistance. NF κB can serve as an ideal target molecular approach to the promising gene therapy.This article reviews recent advances in studies on the structure and function of NF κB, and the relationship between NF κB and prostatic adenocarcinoma infiltration, metastasis and tactics of gene therapy.