TIMI危险积分与冠状动脉病变的相关性研究(英文)

STUDY ON THE CORRELATIVITY BETWEEN CORONARY ARTERY PATHOLOGICAL CHANGE AND TIMIRISK SCORE

目的 探讨冠心病患者TIMI (theThrombolysisinMyocardialInfarction)危险积分与冠脉病变范围、狭窄程度及病变性质的相关关系 ,明确TIMI危险积分对冠脉病变严重程度的评估价值。方法 选择 12 6例冠心病病人为研究对象 ,分析入院时病人TIMI危险积分与其冠脉病变范围、狭窄程度及病变性质的相关性 ;比较TIMI危险积分判别病人冠脉病变范围、狭窄程度及病变性质的ROC(residentoperationcharacter)曲线下面积大小的差异 ,评价TIMI危险积分对病人冠脉病变严重程度的判别价值。结果 TIMI危险积分与病人冠脉病变范围、狭窄程度及病变性质分级均成正相关 ,即TIMI积分越高 ,冠脉病变越重。冠脉病变狭窄程度的ROC曲线下面积最大 ,而冠脉病变性质的ROC曲线下面积最小 ,冠脉病变狭窄程度的ROC曲线下面积明显大于狭窄程度及病变性质的ROC曲线下面积 (P <0 .0 5 ) ,而狭窄程度和病变性质的ROC曲线下面积比较差异无显著性意义 (P >0 .0 5 )。结论 TIMI危险积分能间接反映冠脉病变的狭窄程度及一定程度上反映冠脉病变范围、病变性质的严重程度。TIMI危险积分对冠脉狭窄程度的判别价值较高 ,对冠脉病变性质及范围的判别价值相对较低。

Objective:To study the correlativity between TIMI (the Thrombolysis in Myocardial Infarction) risk score and narrow severity, pathological changes limits and character of coronary artery respectively and to explicit the value of coronary artery pathological change evaluated with TIMI risk score.Methods:All of 126 patients with CAD were enrolled in study. TIMI risk score and coronary artery angiographic in them were performed respectively. Correlativity between TIMI risk score and narrow severity, pathological changes limits and character of coronary artery were analyzed; areas under of the ROC (resident operation character) of TIMI risk scores were compared among narrow severity, pathological changes limits and character of coronary artery; the value of coronary artery pathological change evaluated with TIMI risk score.Results:TIMI risk scores significantly correlated with narrow severity score, pathological changes limits and character scores of coronary artery respectively. TIMI risk score increased company with severity of coronary artery pathological changes advancing. The areas under of ROC(resident operation character) of TIMI risk score for narrow severity was largest. Areas under ROC of TIMI risk score for coronary artery character was least. Significantly difference were found when compared specificity between areas under ROC of TIMI risk score for narrow severity and pathological changes limits as well as coronary artery character (P<0.05).Conclusions:TIMI risk score could be used to evaluate severity of pathological changes character of coronary artery. TIMI risk score have bigger value in evaluating coronary narrow severity than in evaluating pathological changes limits and coronary artery character.