1Herman JG,Graff JR,Myohanen S,et al.Methylaiton-Specific PCR: a novel PCR assay for methylation status of CpG islands[].Proceedings of the National Academy of Sciences of the United States of America.1996
2Jahr S,Hentze H,Englisch S,et al.DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells[].Cancer Research.2001
3Anker P,Lefort F,Vasioukhin V,et al.K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer[].Gastroenterology.1997
4Mulcahy HE,Lyautey J,Lederrey C,et al.A prospective study of K-ras mutations in the plasma of pancreatic cancer patients[].Clinical Cancer Research.1998
5Wong IH,Lo YM,Zhang J,et al.Detection of aberrant p16 methylation in the plasma and serum of liver cancer pa-tients[].Cancer Research.1999
6Silva JM,Dominguez G,Villanueva MJ,et al.Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients[].British Journal of Cancer.1999
7Esteller M,Sanchez-Cespedes M,Rosell R, et al.Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients[].Cancer Research.1999
8Sanchez-Cespedes M,Esteller M,Wu L,et al.Gene promoter hypermethylation in tumors and serum of head and neck cancer patients[].Cancer Research.2000
2Munot K,Bell SM,Lane S,et al.Pattern of expression of genes linked to epigeneic silencing in human breast cancer[J].Hum Pathol,2006,37(8):989-999.
3Leon SA,Shapiro B,Sklaroff DM,et al.Free DNA in the serum of cancer patients and the effect of therapy[J].Cancer Res,1977,37(3):646-650.
4Mirza S,Sharma G,Prasad CP,et al.Promoter hypermethylation of TMS1,BRCA1,ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients[J].Life Sci,2007,81(4):280-287.
5Herman JG,Graff JR,Myohanen S,et al.Methylation-specific PCR:a novel PCR assay for methylation status of CpG islands[J].Proc Natl Acad Sci USA,1996,93(18):9821-9826.
6Uchikura K,Takao S,Nakajo A,et al.Intraoperative molecular detection of circulating tumor cells by reverse transcription-polymerase chain reaction in patients with biliary-pancreatic cancer is associated with hematogenous metastasis[J].Ann Surg Oncol,2002,9(4):364-370.
7Li S,Rong M,Iacopetta B.DNA hypermethylation in breast cancer and its association with clinicopathological features[J].Cancer Lett,2006,237(2):272-280.
8Ruas M,Peters G,Shen M,et al.The p16INK4aPCDKN2A tumor suppressor and its relatives[J].Biochim Biophys Acta,1998,13(8):115-117.
9Issa JP.DNA methylation as a therapeutic target in cancer[J].Clin Cancer Res,2007,13(6):1634-1637.