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JNK/MAPK途径调控机制研究进展 被引量：3

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摘要 JNK信号途径与多种疾病的发病机制有关 ,如癌症、中风、鳞皮病、心脏病、发炎和神经萎缩等疾病。抑制JNK途径的药物具有一定的临床应用价值 ,因此JNK是一个分子治疗靶。JNK信号途径中的各成员相互作用的机制是目前研究热点之一 。
作者 张文伶 金勇丰 朱成钢 张耀洲
机构地区 浙江大学生物化学研究所
出处 《癌变．畸变．突变》 CAS CSCD 2003年第4期253-256,共4页 Carcinogenesis,Teratogenesis & Mutagenesis
关键词 JNK 相互作用 停泊位点 支架蛋白
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

  • 1Gupta S, Barrett T, Whitmarsh A J, et al. Selective interaction of JNK prote in kinase is forms with transcription factors[J]. EMBOJ, 1996,15:2760- 2770.
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  • 3Davis RJ. Signal transduction by the JNK group of MAP kinases[J]. Cell, 2000, 103:239 - 252.
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同被引文献49

  • 1方肇勤,潘志强,汤伟昌,付晓伶,卢文丽,陈晓.小鼠“四诊工作站”构建与操作标准探讨[J].上海中医药大学学报,2006,20(1):42-46. 被引量：64
  • 2袁辉,杨胜,周文霞,张永祥.MAPK级联信号通路与长时程增强[J].中国药理学通报,2006,22(7):769-774. 被引量：38
  • 3NAAMAN-REPERANT E, HALES DB, DURAND P. Effect of transforming growth factor beta-1 on the cholesterol side-chain cleavage system in the adrenal gland of sheep fetuses and newborns [J] . Endocrinology, 1996, 137 (3): 886-892.
  • 4WOLF N, KROHN K, BIEGER S, et al. Transforming growth factor beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro [J] . Neuroscience, 1999, 90(2) : 629 -641.
  • 5MURATA T, KOIDE N, TSUBOI M, et al.Autocrine TGF-beta signaling is required for the GDNF/CNTF-induced neuronal differentiation of adrenal ehromaffin tsAM5D cells expressing temperature-sensitive SV40 T-antigen [J] . Neurosci Lett, 2008, 438 ( 1 ) : 42 - 47.
  • 6GORDON KJ, BLOBE GC. Role of transforming growth factor-beta superfamily signaling pathways in human disease [J]. Biochim Biophys Acta, 2008, 1782 (4): 197-228.
  • 7JUNTTILA MR, LISP, WESTERMARCK J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell surviva [J] . FASEB J, 2008, 22 (4): 954 -965.
  • 8RAMAN M, CHEN W, COBB MH. Differential regulation and properties of MAPKs [J] . Oncogene, 2007, 26 (22) : 3100 -3112.
  • 9XIA W, LONGAKER MT, YANG GP. p38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts [J] . Am J Physiol Regul Integr Comp Physiol, 2006, 290 (3) : R501 -508.
  • 10SCHINDLER JF, MONAHAN JB, SMITH WG. p38 pathway kinases as anti-inflammatory drug targets [ J ] . J Dent Res, 2007, 86 (9) : 800 -811.

引证文献3

二级引证文献6

癌变．畸变．突变
2003年 第4期

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