绝经前行子宫切除术后测定血浆TXA_2和PGl_2的临床意义

STUDY ON THE LEVEL OF PLASMA TXB_2 AND 6-KETO-PGF_(1α)AND CLINICAL SIGNIFICANCE IN CASES OF POSTHYSTERECTOMIZED WOMEN

为研究子宫切除术后患者血浆TXA_2和PGI_2与血管舒缩功能失调的关系,作者测定了绝经前因子宫肌瘤而行全子宫切除45例及未行手术的45名同龄正常妇女的血浆TXB_2和6-keto-PGF_(1a)。结果表明,宫切组的TXA_2、PGI_2显著高于正常对照组,术后这二者的异常致使血管舒缩严重失调,术后4年二者比值逐渐升高,而且TXA_2上升,宫切组患者冠心病发病率增高可能与此有关。

It was discovered that the concentrations of plasma TXB_2 and 6-keto-PGF_(1(?))in cases of posthysterectomized group were markedly high-er than that of nonhysterectomized healthy women or control group with same age.It was demonstrated that the special function of TXA_2 and PGI_2 which can cause vasomotion might be the reason for the serious vasomotor instability of the hysterectomized women.There were higher degree of posi- tive relationship in group of hysterectomized cases than that of the control group.This means that there are some compensation mechanisms of synthesis and secretion between TXA_2 and PGI_2.The mechanism of compensation is able to defend cardiovascular system from the effect of injury due to the abnormal rising of concentrations of TXA_2 or PGI_2.The rising of TXB_2/6-keto-PGF_(1(?)),which means TXA_2 superiority after 4 years postoperation might be the reasons of higher incidence of cardiovacular disease in hyster-ectomized women.