自制脂膜氟碳声学造影剂对肾髓质血流灌注的评价及潜在价值

Assessment of Renal Medulla Blood Flow Perfusion with a Self-Made Liposome Perfluorocarbon Contrast Agent and Its Potential Applications

目的 探讨自制脂膜氟碳声学造影剂“脂氟显”评价肾髓质血流灌注的可行性及潜在价值。方法 10只健康家兔经耳缘静脉团注 0 .0 1ml/kg的脂氟显 ,采用视觉评分和视频分析 ,观察肾髓质的二维灰阶增强效果 ,并与皮质比较。结果 脂氟显能明显增强肾髓质的灰阶显像 ,但与皮质 (持续 5 2′)比较 ,持续时间较短 (约 2′2 0″)。结论 脂氟显可评价肾髓质的血流灌注 ,具有潜在的诊断价值。

Objective To investigate the feasibility and potential usefulness of renal medulla blood flow perfusion with a self made liposome perfluocarbon ultrasound contrast agent. Methods Ten normal rabbits kidneys were imaged with second harmonic imaging before and after intravenous injection of the liposome contrast agent at a dose of 0.01ml/kg. The subjective scores and video intensities were used to evaluate and compare the grey scale enhancement effects of renal medulla and cortex. Results The renal medulla grey scale imaging was greatly enhanced after the injection,but the enhancement time of renal medulla was shorter than that of renal cortex. The notable enhancement time of renal medulla and cortex were 2′20″,52′,respectively. Conclusion The self made liposome perfluocarbon contrast agent can be used for evaluation of renal medulla blood flow perfusion and has a potential diagnostic value.