体外血脂分离术血脂分离效果观察

Observation of effect of in vitro blood lipid separation

目的探讨采用体外肝素诱导低密度脂蛋白形成复合物沉淀而使血脂被分离的方法 (HELP)对低密度脂蛋白(LDL C)、总胆固醇 (TCH)、甘油三酯 (TG)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)和高密度脂蛋白胆固醇 (HDL C)的分离清除的效果。方法用HELP血脂分离仪在体外肝素诱导LDL C、脂蛋白、纤维蛋白原、甘油三酯 ,形成肝素 LDL C 纤维蛋白原复合物而被沉淀分离出来。结果血脂分离术后患者血脂各项指标比术前下降的百分率分别是ApoA 2 4 .50 % ,ApoB 49.1 5 % ,LDL C 50 .33 % ,TCH 51 .40 % ,TG 54 .1 7% ,LDL C 64 .1 1 %。血脂分离术前后血清血脂测定结果比较 ,各测定指标显著降低 (P <0 .0 0 1 )。其中 3例术后 1个月复查血清LDL C、TCH、TG结果与术前结果比较无显著性差异。

Objective To explore the effect of heparin abduction plasma li pid separation on the clearance of low-density lipid protein-c(LDL-c),total c holesterol(TCH),triglyceride(TG),apoliprotein A(ApoA),apoliprotein B(ApoB)and hi gh-density lipid-c(HDL-c).Methods LDL-c,lipoprotein,fibrino gen,and TG were induced by hebarin in HELP lipid separation appliance to form he parin-LDL-C-fibrinogen complex.Results ApoB and LDL-C after separation were 49.51% and 50.33%,respectively.Each index of serum lipid before and after separation was remarkably decreased(P<0.001).1 month later after separation in 3 cases,the reexamination results of LDL-C,TCH,and TG were not significantly different compared with that before separation.C onclusions HELP can clean part of the plasma lipid.