摘要
AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopdde 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.RESULTS: Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2%±5.5%, 81.7%±8.5% vs70.5%±9.2%, P<0.01;91.2%±2.2%, 91.3%±3.9% vs86.8%±2.6%, P<0.01).The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0%±11.7%, 77.1%±11.9% vs 66.3%±13.6%, P<0.01, P<0.05; 83.2%±5.5%, 81.7%±8.5% vs75.4%±5.9 %, P<0.01, P<0.05; 91.2%±2.2%,91.3%±3.9% vs 88.6%±3.5%,P<0.05, P<0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P>0.05).CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.
AIM:To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatment of gastrointestinal motility diseases. METHODS:Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal,which reflexes gastrointestinal motility function.120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control),prucalopride 1 mg/kg,prucalopride 2 mg/kg and cisapride 1 mg/kg, respectively.The gastrointestinal propulsion rate was measured 1,2 or 4 hours after intravenous injection of the drugs. RESULTS:Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2 %±5.5 %,81.7 %±8.5 % vs70.5 %±9.2 %,P<0.01; 91.2 %±2.2 %,91.3 %±3.9 % vs86.8 %±2.6 %,P<0.01). The gastrointestinal propulsion rates at 1,2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0 %±11.7 %,77.1%±11.9 % vs 66.3 %±13.6 %,P<0.01,P<0.05;83.2 %±5.5 %,81.7 %± 8.5 % vs75.4 %±5.9 %,P<0.01,P<0.05;91.2 %±2.2 %, 91.3 %±3.9 % vs 88.6 %±3.5 %,P<0.05,P<0.05).No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P>0.05). CONCLUSION:Prucalopride accelerates intestinal motility in fast rats,and has no dose dependent effect.