摘要
AIM: To study the therapeutic effectiveness of intra-tumorinjection of Xiao-Zhi-Ling(XZL) on transplanted hepatomain rats.METHODS: Sixty rats were divided into 3 groups (groupsS, X and E), 20 in each. Different drugs were injected intothe implanted hepatoma (Group S with 0.2 mi saline ascontrol, group X with 0.2 mi XZL, group E with 0.2 miethanol). After 3 days and 8 days respectively, we detectedthe hepatoma volume (HV), the level of albumin, alanineaminotransferase (ALT), aspartate aminotransferase (AST)and alkaline phosphatase (ALP) in serum, and the expressionof proliferating cell nuclear antigen (PCNA) in hepatoma.RESULTS: The results were obtained after 3 days, the HVsin groups X and E were smaller than those in group S (groupX vs S P=0.010*, group Evs S P=0.002*, P＜0.05). Thelevels of ALT and AST in group S and X were lower thanthose in group E (ALT Group S vs E P=0.019*, group X vsEP=0.003*, P＜0.05; AST group X vs E P=0.002*, P＜0.05).The levels of ALP and PCNA labeling index in group X werelower than those in group S and E (ALP group X vs SP=0.000*, group X vs E P=0.000*. P＜0.05; PCNA group XvsS P=0.008*, group X vsE P=0.048*, P＜0.05). The levelsof creatinine in group S were lower than those in group E(group S vs E P=0.017, P＜0.05). The degree of tumornecrosis in group S was lower than those in groups X and E(group S vsX P=0.006*, group S vs E P=0.006*, P＜0.05).After 8 days, the HVs in groups X and E were smaller thanthose in group S (group X vs S P=0.007*, group Evs SP=0.004*, P＜0.05). The difference of HVs between groupsX and E was not significant. The levels of albumin, ALT, ASTand creatinine in group X were not higher than those inother groups, the levels of ALP and PCNA in group X werelower than those in groups S and E (ALP group X vs EP=0.006* P＜0.05; PCNA group X vsS P=0.044*, group Xvs E P=0.021*, P＜0.05). The degree of tumor necrosis ingroup S was lower than that in groups X and E (group S vsX P=0.001*, group S vs E P=0.002*, P＜0.05).CONCLUSION: The therapeutic effectiveness of intra-tumorinjection of XZL and ethanol on implanted hepatoma isobvious, but the toxicity of XZL on liver function is markedlylower than that of group E, at the same time XZL can inhibitthe growth of tumor. XZL is relatively better and safer thanethanol in intra-tumor injection therapy.
AIM:To Study the therapeutic effectiveness of intra-tumor injection of Xiao-Zhi-Ling(XZL) on transplanted hepatoma in rats. METHODS:Sixty rats were divided into 3 groups (groups S,X and E),20 in each.Different drugs were injected into the implanted hepatoma (Group S with 0.2 ml saline as control,group X with 0.2 ml XZL,group E with 0.2 ml ethanol).After 3 days and 8 days respectively,we detected the hepatoma volume (HV),the level of albumin,alanine aminotransferase (ALT),aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in serum,and the expression of proliferating cell nuclear antigen (PCNA) in hepatoma. RESULTS:The results were obtained after 3 days,the HVs in groups X and E were smaller than those in group S (group X vs S P=0.010~*,group E vs S P=0.002~*,P<0.05).The levels of ALT and AST in group S and X were lower than those in group E (ALT Group S vsE P=0.019~*,group X vs E P=0.003~*,P<0.05;AST group X vs E P=0.002~*,P<0.05). The levels of ALP and PCNA labeling index in group X were lower than those in group S and E (ALP group X vs S P=0.000~*,group X vs E P=0.000~*.P<0.05;PCNA group X vsS P=0.008~*,group X vsE P=0.048~*,P<0.05).The levels of creatinine in group S were lower than those in group E (group S vs E P=0.017,P<0.05).The degree of tumor necrosis in group S was lower than those in groups X and E (group S vs X P=0.006~*,group S vsE P=0.006~*,P<0.05). After 8 days,the HVs in groups X and E were smaller than those in group S (group X vs S P=0.007~*,group E vs S P=0.004~*,P<0.05).The difference of HVs between groups X and E was not significant.The levels of albumin,ALT,AST and creatinine in group X were not higher than those in other groups,the levels of ALP and PCNA in group X were lower than those in groups S and E (ALP group X vs E P=0.006~* P<0.05;PCNA group X vsS P=0.044~*,group X vs E P=0.021~',P<0.05).The degree of tumor necrosis in group S was lower than that in groups X and E (group S vs X P=0.001~*,group S vs E P=0.002~*,P<0.05). CONCLUSION:The therapeutic effectiveness of intra-tumor injection of XZL and ethanol on implanted hepatoma is obvious,but the toxicity of XZL on liver function is markedly lower than that of group E,at the same time XZL can inhibit the growth of tumor.XZL is relatively better and safer than ethanol in intra-tumor injection therapy.
