角燕胶囊的毒理学实验研究

Toxicological study on Mobulidae Capsule

〔目的〕对海洋生物提取物角燕胶囊进行毒理学安全性评价。〔方法〕通过急性毒性试验、3 0d喂养试验以及致突变试验对角燕胶囊进行毒性评价。〔结果〕 ( 1)角燕胶囊的急性毒性试验LD50 大于每公斤体重 10 .0g ,表明属无毒级样品 ;( 2 )Ames试验、骨髓微核试验、精子畸形试验均为阴性结果 ;( 3 ) 3 0d喂养试验显示角燕胶囊无毒性 ,无体内蓄积中毒。〔结论〕角燕胶囊属无毒级产品 ,无致突作用 ,无遗传毒性 ,无明显体内蓄积中毒。

objective〕 To estimate the toxicological characterization of Mobulidae Capsule. 〔Methods〕 the acute toxicity test, micronucleus test of bone marrow cell, sperm shape abnormality test in mice, the Ames test, and 30 days feeding test in rat was studied. 〔Results〕 (1)The acute toxicity test showed that the LD 50 of Mobulidae Capsule was more than 10.0g/kg. (2)The result of Ames test, micronucleus test of bone marrow cell, and sperm shape abnormality test was negative. (3) the 30 days feeding test showed that the Mobulidae Capsule have no cumulate toxicity in mice. 〔Conclusion〕 The results showed that the Mobulidae Capsule have no toxicity, and it can't cause mutation and heredity toxicity.