摘要
用全反式维甲酸治疗急性早幼粒细胞白血病13例,12例获完全缓解,1例部分缓解。维甲酸促进早幼粒细胞诱导分化并逐渐成熟,外周血白细胞升高是其治疗作用的最早标志,成熟粒细胞中出现Auer小体证实了该药的诱导分化作用,使用该药不产生骨髓抑制,不诱发DIC。
Thirteen patients with acute promyelocytic leukemia(APL) were treated with all-trans retinoic acid.Twelve achieved complete remis-sion(CR),one partial remission.The CR are obtained by differentia-tion process,The presence of Auer rods in maturing cells confirmed the differentiation effect of retinoie acid,An increase of WBCs were the first signs of all-trans retinoic acid efficacy.CR were obtained without bone marrow hypoplasia and DIC,Among the patients in CR,nine received the following maintenance treatment.
出处
《山东医科大学学报》
1992年第4期315-317,共3页
Acta Academiae Medicinae Shandong
关键词
维甲酸
白血病
髓母细胞性
Tretinoin
Leukemia,myelocytic,acute
Treatment
