κ和λ轻链标记对淋巴网状组织病变病理诊断的意义

EVALUATION OF KAPPA AND LAMBDA LIGHT CHAIN ASSAYS IN DIFFERENTIAL PATHOLOGIC DIAGNOSIS OF LYMPHORETICULAR DISEASES

对86例淋巴网状组织疾病进行抗κ和λ轻链抗血清标记。结果表明,淋巴组织反应性增生均为多克隆性。35例B细胞恶性淋巴瘤中,单克隆9例,大致单克隆15例,多克隆11例。提示单克隆和大致单克隆对确诊B细胞性恶性淋巴瘤有重要价值,多克隆性标记并不能完全排除恶性淋巴瘤的诊断。

Eighty-six cases of lymphoreticular diseases were reviewed on the basis of parafin-embeded tissue blocks with PAP method for kappa and lambda light chain.The results demonstrated that all the reacting lymphoid hyperpiasias were mutiple colonal with both kappa and lambda light chain positive cells.In the 35 cases of B cell lymphomas there were 9 monocolo-nal,15 relative monocolonal,11 mutiple colonal.It was suggested that mono- colonal and relative monocolonal were helpful in ditermining the diagnosis of B cell malignant lymphomas,but multiple colonai could not rule out the diagnosis.