他汀类药物早期干预对急性冠脉综合征患者血脂、高敏C反应蛋白和纤维蛋白原的影响

Influence of early intervention with Statins on the levels of total cholesterol, low density lipoprotein, high sensitivity C-reactive protein and fibrinogen in patients with acute coronary syndrome

目的 比较他汀类药物和阿司匹林联合用药与单用阿司匹林对急性冠脉综合征患者血脂、高敏C反应蛋白及纤维蛋白原的影响。方法 所有患者均在急性冠脉综合征发病后 72h内开始接受药物治疗 ,他汀组 (40例 )应用他汀类药物加阿司匹林治疗 8周 ,对照组 (16例 )单用阿司匹林治疗 ,观察两组总胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白和纤维蛋白原水平的变化。结果 治疗 8周后 ,他汀组各指标显著降低 ,而对照组仅高敏C反应蛋白水平显著下降。他汀类药物降低高敏C反应蛋白、纤维蛋白原的程度与其降脂作用无关。结论 他汀类药物与阿司匹林联合用药降低高敏C反应蛋白和纤维蛋白原的作用可能优于单用阿司匹林 ,并与其抗炎作用有关。

Objective To compare the effects of combined Statins with Aspirin and Aspirin alone on TC,LDL-C, hsCRP, Fg levels in patients with acute coronary syndrome.Methods All patients received the drug therapy within 72 hours after onset of symptoms. With administration of statins combined with aspirin (n=40) and aspirin alone(n=16) for eight weeks,serum levels of TC,LDL-C,hsCRP and plasma Fg were measured before and after the treatment.Results After treatment for eight weeks,in patients treated with statins and aspirin, the TC,LDL-C,hsCRP and Fg levels decreased significantly. Whereas in the control group only decrease of hsCRP level could be seen.Conclusion Comparing with the use of aspirin done, Statins coupled with Aspirin show better effects on decrease of TC, LDL-C, hsCRP and Fg levels in acute coronary syndrome.