红花注射液对肺心病患者血粘度、血小板及抗凝纤溶功能的影响

The effect of Carthamus tinctorius injection on blood viscosity, function of platelet , anticoagulation and fibrinolysis of the patient with cor pulmonale

目的:探讨红花注射液对肺心病患者血粘稠度、血小板、凝血、纤溶的影响。方法:60例肺心病急发期患者随机分成两组。对照组30例给予常规治疗,红花组30例在常规治疗基础上加用红花注射液30mL静滴,每日1次,疗程15d。观察病人疗效及治疗前后血粘度、最大血小板聚集率(PAgT-Max)、血小板颗粒膜蛋白(GMP-140)、纤溶酶原(PLg)、组织型纤溶酶原激活物(tpA)的水平变化。与正常对照者相比较。结果:对照组总有效率86.7％,显效率30％。红花组总有效率93％,显效率60％。红花组显效率明显高于对照组(P<0.01)。红花组治疗后血粘度、血小板指标与治疗前对照明显降低(P<0.01-0.05),抗凝、纤溶活性水平明显高于治疗前(P<0.01-0.05)。对照组治疗后较治疗前PLg、抗凝血酶(AT-Ⅲ)显著升高(P<0.05),tpA差异不显著(P>0.05)。结论:肺心病急发期患者处于血栓前状态,红花注射液对肺心病血栓前状态有明显改善作用,对肺心病治疗具有临床价值。

OBJECTIVE:To explore the effect of Carthamus tinctorius injection on blood viscosity, platelet , elotting and fibrinolysis in the patients with cor pulmonale. METHODS: 60 patients with acute cor pulmonale are divided into two groups. The 30 patients of control group are treated with routine drugs, the other 30 patients of Carthamus tinctorius group are treated with Carthamus tinctorius (30mL, qd, for 15d as a course) on the basement of routine treatment. Examine the patients' blood viscosity, PAgT-Max, granular membrane protein ( GMP -140), plasminogen (PLg) and tissue-type plasminogen activator ( tpA) of pre- and after the treatment. RESULTS: The total efficient rate of contral group is 86. 7% , and its notable efficient rate is 30% ; While in the Carthamus tinctorius group these two figures are 93 % and 60 %. The notable efficient rate in Carthamus tinctorius group is significantly higher than that of control group, (P <0. 01 ). After the treatment, the blood viscosity and platelet index of Carthamus tinctorius are significantly lower than before ( P < 0. 01 - 0. 05 ) . The antithrombotic and fibrinhlysis activity are significantly higher than that of before the treatment, the PLg, anti thrombin Ⅲ ( AT -Ⅲ ) are significantly higher than before , but the tpA has no significant difference ( P > 0. 05 ) . CONCLUSION: The acute cor pulmonale is in a pre-thrombotic state, the Carthamus tinctorius injection can notablely inprove this state, and it suggests that the Carthamus tinctorius injection may play a role in clinical to treat cor pulmonale.