摘要
目的 研究三碘甲状腺原氨酸 (T3)对肿瘤细胞化疗的增敏作用。方法 MTT比色法 ;结果 (1)T3的作用对人肺巨细胞癌细胞株 (PLA 80 1D)的生长无明显影响 ,与PLA 80 1D作用后T3的浓度无明显变化。 (2 )经T3作用后能提高鬼臼乙叉甙 (Vp 16 )对PLA 80 1D的抑制率 ,而且这种增敏作用在T3持续存在时更明显。T3对Vp 16的增敏作用与T3作用的时间和浓度无明显相关性。 (3)T3对顺铂 (DDP)无增敏作用。结论 三碘甲状腺原氨酸对Vp 16有一定增敏作用。
Objective The effect of triiodothyronine (T3) on drug sensitivity of Vp-16 and DDP to PLA-801D(human lung giant call cancer line)was investigated in-vitro.Methods MTT assay was used .Results (1) T3 had no effect on the proliferation of PLA-801D. The concentration of T3 had no obvious change after the T3 effected on PLA-801D. (2)T3 was found to enhance significantly the anticancer activity of Vp-16 as long as T3 was present. There was no correlation between the chemosensitivity and the T3’s concentration and the action time. (3) T3 could not sensitize PLA-801D to DDP. Conclusion T3 could sensitize PLA-801D to the anticancer activity of Vp-16 in-vitro.
出处
《肿瘤》
CAS
CSCD
北大核心
2003年第5期376-379,共4页
Tumor
基金
军队科研<十五>面上基金资助项目 (编号 0 1MA10 2 )
