摘要
目的 分析西南地区鼻和鼻型NK/T细胞淋巴瘤的临床病理特征及影响预后的因素。方法 分析 12 0例鼻和鼻型NK/T细胞淋巴瘤的病理形态及免疫表型、临床特点、治疗和生存情况。结果 12 0例患者总的 5年生存率为 5 4 .1%。大型瘤细胞生存率较中小型瘤细胞低 (P <0 .0 1) ,病变中有坏死及血管浸润者生存率明显低于对照组 (P <0 .0 5 ) ,而瘤细胞分布及患病年龄与预后关系不大 ,临床Ⅰ～Ⅱ期与Ⅲ～Ⅳ期两组病例生存率差异有显著性 (P <0 .0 1) ,累及多个部位、伴有穿孔及全身症状者生存率低于对照组 (P <0 .0 5 )。综合治疗疗效优于单一治疗及未治疗组 (P <0 .0 1) ,单一治疗近期疗效好 ,而远期疗效与未治疗组差异无显著性 (P >0 .0 5 )。CoxRegression分析结果亦表明瘤细胞大小、分期及治疗方法与预后密切相关。 结论 瘤细胞大小、坏死、血管浸润、穿孔、B症状、分期、病变范围和治疗方法与鼻和鼻型NK/T细胞淋巴瘤的预后相关 ,其中瘤细胞大小、分期和治疗方法是其主要的预后因素。
Objective To investigate the clinicopathologic features, prognostic factors and the prognosis of nasal and nasal-type NK/T-cell lymphoma in south-west of China. Methods The clinicopathologic features, immunophenotypes and treatment of 120 patients with nasal and nasal-type NK/T-cell lymphoma were analyzed. Results The overall 5-year survival rate for all cases was 54.1%, and correlated well with the size of tumor cells, necrosis, angiocentricity, the stage, sites of involvement, and perforation(P<0.05); but not with the distribution of tumor cells and the age of patients at the presentation (P>0.05). The overall survival rate of patients with combined therapy was higher than that of patients with radiotherapy or chemotherapy alone or untreated ones (P<0.01). Even though the patients with radiotherapy or chemotherapy alone had a relatively favorable short-term results, the long-term curative effect for those patients was not better than that of untreated patients (P>0.05). Furthermore, the size of tumor cells, stage, and treatment were well correlated with the prognosis of these patients by Cox Regression. Conclusion The prognosis of nasal and nasal-type NK/T-cell lymphoma was significantly correlated with the size of tumor cells, necrosis, angiocentricity, stage, sites of involvement, perforation and treatment, especially with the size of tumor cells, stage, and treatment.
出处
《肿瘤》
CAS
CSCD
北大核心
2003年第5期411-413,共3页
Tumor
基金
国家自然科学基金资助项目 (编号 :3 910 0 0 47)
