诺维本联合顺铂治疗阿霉素类药物耐药性的晚期乳腺癌的疗效

Effect of navelbine(NVB) combined with cisplatin(DDP) in treatment of adriamycin(ADM) resistant advanced breast carcinoma patients

目的 观察诺维本 (Navelbine,NVB)联合顺铂 (DDP)治疗阿霉素耐药性的晚期乳腺癌疗效及毒副反应。方法 对 36例乳腺癌术后复发转移者 ,且全部为阿霉素治疗后转移或复发的晚期乳腺癌患者。NVB 2 5mg/m2 ,静脉滴入 ,d1、d8;DDP 30mg/m2 静脉滴入 ,第d1～d3,2 1天为 1周期 ,全组化疗共 90周期 ,中位数 2 .5周期 (2～ 4周期 )。结果 36例患者中有效率为6 1.1% (2 2 /36 ) ,CR 4例 ,PR18例 ,SD 10例 ,PD 4例。主要毒性为骨髓抑制 ,以白细胞减少为主 ,其发生率为 88.9%。本组绝大多数经锁骨下静脉置管给药 ,故静脉炎的发生率很低 ,其他毒性轻微。结论 NVB +DDP治疗阿霉素类药物耐药性的晚期乳腺癌疗效较好 ,且毒性可以耐受 ,值得临床推广应用。

Objective To observe the therapeutic effects of NVB combined with DDP in the treatment of ADM-resistant advanced cases of breast cancers.Methods 36 cases of advanced breast cancers had been treated with ADM with recurrence and/or metastases were studied. The treatment consisted of NVB 25 mg/m2 i.v. on day 1 and day 8; DDP 30 mg/m2 i.v. from day 1 to day 3; 21 days a cycle. Altogether 90 cycles were given with a median of 2.5 cycles(2-4 cycles). Results Among the 36 cases, there were CR 4 cases, RP 18 cases,SD 10 cases and PD 4 cases. The all over response rate was 61.1%(27/36). The main toxic effects were bone marrow suppression,mainly leukopenia in 88.9%.The incidence of phlebitis was very low, since in most cases drugs were given through subclavicle vein intubation. Conclusion For ADM-resistant advanced cases of breast cancer, NVB combined with DDP is an effecfive method of treatment and the toxic effect are tolerable.