β-catenin和Cyclin D1在肝癌肝内转移中的作用

Role of β-catenin and cyclin D1 expressions in intrahepatic dissemination of liver cancer

目的:探讨β-catenin和 Cyclin D1与癌栓形成及临床病理参数的关系.方法:用免疫组化法检测32例肝癌原发灶、癌栓和癌旁组织中β-catenin、Cyclin D1的表达,同时分析其与临床病理参数之间的关系.结果:β-catenin在原发灶、癌栓和癌旁组织中的阳性率分别为62.5％、81.25％、9.38％,三者之间有显著差别;β-catenin与癌栓形成、HBV感染、肝硬化有关.CyclinD1在原发灶、癌栓和癌旁组织中的阳性率分别为46.9％、75％、18.8％,三者之间有显著差别;Cyclin D1与癌栓形成、组织类型、分化程度有关.结论:β-catenin和 Cyclin D1促进癌栓形成,参与HBV感染和肝硬化形成过程;Cyclin D1影响肿瘤组织类型和分化程度.

AIM: To analyze the relationship between expressions of β-catenin and cyclin D1 and formation of portal vein tumor thrombus and clinical pathologic parameters. METHODS: β-catenin and Cyclin D1 were tested in primary liver cancer, tumor thrombus and paracancer tissue in 32 cases of hepatic carcinoma with immunohistochemistry. Their effect on clinic pathologic paramerers was also discussed. RESULTS: The positive rates of β-catenin expression in primary liver cancer, tumor thrombus and paracancer tissue were 62.5 %, 81.25 %, and 9.38 %, respectively. The positive rates of β-catenin expression were also correlated with tumor thrombus, HBV infection and liver cirrhosis. The positive rates of cyclin D1 expression in primary liver cancer, tumor thrombus and paracancer tissue were 46.9 %, 75 %, and 18.8 %, respectively. It was also correlated with tumor thrombus, cell classification and differentiation. There were obvious differences among three groups in expression of β-catenin and cyclin D1. CONCLUSION: β-catenin and cyclin D1 are helpful for ini- tiation and progression of tumor thrombus and play an important role in the course of liver cirrhosis and HBV infection. Cyclin D1 influences tumor classification and differentiation.