老年急性白血病MIC特征

The MIC feature in the elderly with acute leukemia

目的 研究老年急性白血病(AL)免疫学等生物学特征。方法 对51例老年AL进行形态学、免疫学和细胞遗传学(MIC)分型实验研究。结果 ①急性髓系白血病(AML)43例(84.3％),急性淋巴细胞性白血病(ALL)8例(15.7％)。②老年AL免疫表型系列专一性为62.7％、表达二系的为21.6％,而成人对照组分别为92.5％和2.4％,P<0.01。老年AL表达三系的有3.9％、裸细胞型AL为11.8％,而对照组分别为0.7％和4.8％。P<0.05。③各抗原的具体表达在老年AL与对照组中除CD_(42b)外,都无显著差异。④老年AL核型正常27例(52.9％),核型异常24例(47.1％)。⑤形态学与免疫学一致率为84.3％。结论 老年AL以AML为主,表达二系、三系抗原和裸细胞型的比例明显增多。

Objective To study the immunological feature in the elderly with acute leukemia(AL) . Methods Fifly-one cases with acute leukemia were classified in accordance with their morphological, immunological and cytogenetic(MIC) features. Results ①AML accounted for 84.3%(43) of AL in the 51 elderly cases,and ALL accounted for 15.7% (8) .②In the elderly patients,62.7% expressed single lineage and 21.6% two lineages(P < 0.01,versus control,respectively),3.9% express three lineages and 11.8% null cell(.P<0.05, versus control,respectively).③Except CD42b,there was no significant difference in antigen expression in elderly patients compared with the control. ④Of the 51 elderly patients,27 had normal karyotype, and 24 had abnormal karyotype.⑤The consistency rate was 84.5% between morphology and immunology. Conclusions In the elderly patients with AL,AML is the main type. Two lineage, theree lineage and null cell expression increase significantly.