引起医院感染的144株铜绿假单胞菌耐药趋势

Analysis of antimicrobial resistance of 144 strains of Pseudomonas aeruginosa causing nosocomial infection

目的 了解某医院铜绿假单胞菌感染分布及耐药趋势。方法 对 1 997～ 2 0 0 2年某医院感染病例中分离的 1 4 4株铜绿假单胞菌进行统计分析。结果 烧伤创面的铜绿假单胞菌分离率最高 ,达 5 2 .0 8% (75株 ) ;其次为下呼吸道 30 .5 6 % (4 4株 )。 1 997～ 1 999年与 2 0 0 0～ 2 0 0 2年相比 ,铜绿假单胞菌对阿米卡星、哌拉西林、头孢哌酮 /舒巴坦、氨曲南、环丙沙星的耐药性 ,差异有高度显著性 (P <0 .0 1 )。从不同部位标本分离的铜绿假单胞菌对同一种抗菌药物的耐药性差异亦有高度显著性 (P <0 .0 1 )。结论 医院感染的铜绿假单胞菌对大多数抗菌药物耐药且呈增高趋势 ,应重视细菌耐药监测 ,以了解细菌耐药的变迁 。

Objective To investigate the distribution and drug resistance of P.aeruginosa causing nosocomial infection. Methods Data of the 144 strains of P.aeruginosa isolated from patients with nosocomial infection between 1997 and 2002 were analysed. Results Seventy five and 44 strains of P.aeruginosa were isolated from burn site ( 52.08% ) and lower respiratory tract ( 30.56% ). Drug resistance of P.aeruginosa to amikacin, piperacillin, cefoperazone/sulbactam, aztreonam, ciprofloxacin increased significantly from 1997-1999 to 2000-2002. The drug resistance of P. aeruginosa from different specimens to the same drug varied significantly. Conclusions Drug resistance of P.aeruginosa causing nosocomial infection increased in recent years. It is important to pay attention to the bacteria drug resistant surveillance and the rational use of antimicrobial agents.