血管紧张素I转换酶基因多态性与脑卒中关系

The relationship between angiotensin converting enzyme gene polymorphism and cerebral stroke

目的 探讨血管紧张素I转换酶 (ACE)基因多态性与脑卒中关系。方法 应用聚合酶链反应 (PCR)检测了92例脑卒中患者和 15 8例正常人的ACE基因型 ,并用Logistic回归筛选脑卒中的危险因素。结果 ①脑卒中患者的甘油三脂 (TG)、高密度脂蛋白 (HDL)、总胆固醇 (TC)和载脂蛋白 (ApoAI、ApoB)水平与正常人相比 ,均无显著性差异 (P均 >0 .0 5 )。②ACE各基因型在不同性别、年龄间的分布以及在TG、HDL和ApoAI、ApoB等生化指标方面均未有显著性差异 (P均 >0 .0 5 )。③脑卒中患者DD基因型的频率 (2 8.2 6 % )显著高于正常对照组 (15 .19% ) (P <0 .0 5 )。结论 ①ACE基因型与引起脑卒中的其他危险因素 :TG、HDL和ApoAI、ApoB等无关。②ACE基因DD型、年龄是脑卒中的重要危险因素。

Objective To explore the relationship between angiotensin converting enzyme(ACE) gene polymorphism and cerebral stroke. Methods ACE genotype was examined by polymerase chain reaction(PCR) in 92 cerebral stroke patients and 158 normal controls. Logistic regression was used to determine the significant risk factors for cerebral stroke. Results ①There was no significant difference in triglyceride(TG) , high-density lipoprotein-cholesterol(HDL),total cholesterol(TC) and apolipoprotein(Apo)AI, ApoB between cerebral stroke patients and normal controls(P>0.05). ②The frequency of ACE genotype was not associated with sex, age, TG, HDL , TC and ApoAI, ApoB(P>0.05).③The DD genotype was more common in cerebral strokes(28.26%) than in normal controls (15.19%,P<0.05). Conclusion ① There was no correlation between ACE gene polymorphism and other cerebral stroke risk factors: TG, HDL, TC and ApoAI, ApoB, ② The ACE DD genotype, age was significant risk factor for cerebral stroke.