迪康胶囊对二甲基亚硝胺诱导的肝纤维化大鼠星状细胞TGFβⅡ型受体表达的影响

Influence of DiKang capsule on expression of TGFβ receptor Ⅱ on hepatic satellite cells in rat with liver fibrosis introduced by DMN

目的 :探讨迪康胶囊对二甲基亚硝胺 (DMN)诱导的肝纤维化大鼠星状细胞TGFβⅡ型受体表达的干扰作用。方法 :采用流式细胞术检测大鼠星状细胞TGFβⅡ型受体。 结果 :以 10 μg kgDMN注射 3周后停止 ,再灌服迪康胶囊 3周可使大鼠星状细胞TGFβⅡ型受体表达增加 ,而持续以 5 μg kgDMN注射 ,灌服迪康胶囊对TGFβⅡ型受体无影响。 结论 :迪康胶囊对迪康胶囊对二甲基亚硝胺诱导的肝纤维化大鼠星状细胞TGFβⅡ型受体表达有一定增强作用。

Objective:To study the influence of DiKang capsule on expression of TGFβ receptor Ⅱ on hepatic stellite cells(HSC)in rat with liver fibrosis introduced by DMN.Methods:TGFβ receptor Ⅱ on HSC in rat with liver fibrosis introduced by DMN were measured by FCM.Results:In group of 10 μg/kg DMN injected 3 weeks,expression of TGFβ recptor Ⅱ on HSC in these rat fed with DiKang capsule 3 weeks were higher than that not feeding capsule.But in group of injecting 5 μg/kg DMN continuous 6 weeks,expression of TGFβ receptor Ⅱ on HSC does not changed with feeding or not feeding DiKang capsule.Conclusion:DiKang capsule may have a certainly role on expression of TGFβ receptor Ⅱ on HSC in rat with liver fibrosis introduced by DMN.