慢性乙型肝炎患者阿糖腺苷治疗前后肝组织中HBsAg、HBcAg表达

The Expression of HBsAg and HBcAg in the liver tissues of the patients with chronic hepatitis B before and after the treatment with Arabinosydenosine.

探讨慢性乙型肝炎患者阿糖腺苷治疗后肝组织中HBsAg、HBcAg的表达。选择20例慢性乙型肝炎患者,静脉滴注阿糖腺苷400mg qd×60d。治疗前、后分别行肝穿刺活检,用免疫组织化学法(SP)检测其肝组织中HB-sAg、HBcAg。治疗前患者肝组织中HBsAg、HBcAg分别检出20例、18例,治疗后分别减至18例、10例。阿糖腺苷治疗前后肝组织中HBcAg比较,差异有显著意义(P<0.05);HBsAg比较,差异无显著意义(P>0.05)。阿糖腺苷可以有效促使慢性乙型肝炎患者肝组织中HBcAg阴转。

To study the expression of HBsAg and HBcAg in the liver tissues of the patients with chronic hepatitis B before and after the treatment with Arabinosydenosine. Twenty patients (sex: 14 cases male, 6 cases female; ages:33a?a.) with chronic hepatitis [HBVDNA( + ),HBeAg( + ),ALT>40U/L,Bil< 85.5 μmol/L]was treated with arabmosydenosine[400mg veno- Dribbling qd (once each day) × 2M] . Before and after the treatment, the patients were made the liver puncture for detecting HBsAg,HBcAg in the liver tissues by immunohistochemical method (SP) . There are 20 cases HBsAg positive expressing and 18 cases HBcAg positive expressing before the treatment. After the treatment, there are 18 cases HBsAg positive expressing and 10 cases HBcAg positive expressing. Before and after the treatment of arabinosydenosine, in the liver tissues, the detected result of HBcAg has significant difference ( P < 0.05); But the result of HBsAg hasn' t significant difference ( P > 0.05). Arabinosydenosine maybe the utility for the HBcAg in liver tissues got negative express for patients with chronic hepatitis B.