心得安辅助治疗肝源性溃疡疗效观察

The observation of curative effect of propanolol's accessory trentment on hepatogemic ulcer

研究乙肝后肝硬化患者消化性溃疡的临床特点,探讨小剂量心得安对肝源性溃疡愈合的影响。肝源性溃疡124例,观察其发病年龄、溃疡部位、腹痛情况、临床表现、合并出血率、溃疡愈合率等特点。随机分为治疗组,用心得安+奥美拉唑治疗;对照组,用维生素B6+奥美拉唑治疗。另设单纯性消化性溃疡为对照2组,治疗方法与对照组相同。肝源性溃疡发病年龄较单纯性消化性溃疡晚10年,溃疡部位以胃溃疡居多、合并出血率高,心得安可明显提高肝源性溃疡愈合率与对照组具统计学意义(P<O.05)。肝源性溃疡难以治愈且易合并出血,可能是门静脉高压的影响,小剂量心得安有助于肝源性溃疡愈合。

To study the clinical features of peptic ulcer of patients with post - hepatitis B cirrhosis, explore the effect of small dose propranolol on the healing of hepatogenic ulcer. 124 patients with hepatogenic ulcer were randomly divided into two group groups treatment group were given propranolol and omeprazole; control group were given vitamin B6 and omeprazole (C1). Patients with simple peptic ulcer were treated as another control group (C2), using identical medicine with C1. Observe the features of patients' age of ulceration, site of ulceration, abdominalgia, clinical manifestation, incidence of hemorrhage, healing rate of the ulcer. Patients' age of hepatogenic ulceration was 10 years older than patients with simple peptic ulcer, hepatogenic ulcer was mostly gastric and with high incidence of hemorrhage. Propranolol can significantly increase the healing rate of hepatogenic ulcer ( P < 0.05) . Hepatogenic ulcer was intractable and liable to complicate with hemorrhage, portal hypertension may be a contributory factor. Small dose of propranolol can promote the healing of hepatogenic ulcer.