来适可治疗原发性高胆固醇血症的临床观察

Clinical observation of lescol on primary hyperchole sterolemia

目的 :探讨来适可 (氟伐他汀 )治疗原发性高胆固醇血症的临床疗效及治疗机制。方法 :将 12 4例原发性高胆固醇血症患者随机分为治疗组 (来适可每次 2 0mg ,每晚 1次 )和对照组 (舒降之每次 5mg ,每晚 1次 ) ,分别于治疗后 4周、8周、12周后观察其血脂的变化和用药反应。结果 :两组有明显的降TC、TG、LDL作用 ,在升高HDL方面 ,来适可显著优于舒降之 (P <0 .0 5 ) ,未见明显毒副作用。结论 :来适可对原发性高胆固醇血症有较好的疗效是一个十分良好的调脂药。

Objective: To explore the clinical efficacy and treatment mechanism of Lescol (fluvastatin) in the treatment of primary hypercholesterolemia. Methods: One hundred and twenty-four patients with primary hypercholesterolemia were randomly divided into the treatment group (Lescol 20 mg,once every evening) and the control group [Zocor (simvastatin) 10 mg once every evening]. After taking the medicines,the changes of blood lipid and the reactions in the patients were observed at 4 weeks, 8 weeks and 12 weeks ,respectively. Results: The patients in both groups decreased the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) significantly. Lescol was superior to Zocor (P<0.05) in increasing high density lipoprotein (HDL), and there was no apparently adverse reaction.Conclusion: Lescol has a better efficacy in the treament of primary hypercholesterolemia.It is a very good drug in regulating the blood lipid.