咪唑安定镇静与其血药浓度相关性研究

Relationship between midazolam sedation and its blood concentration

目的 研究硬膜外麻醉下咪唑安定临床镇静程度与其血药浓度间的相互关系。方法1 0例ASAⅠ～Ⅱ级、拟在硬膜外麻醉下手术的妇科手术病人接受咪唑安定镇静 ,观察警觉镇静评分(OAA/S)和脑电双频指数 (BIS) ,同时测定血药浓度。对各项指标进行相关性分析。结果 OAA/S与BIS间的相关性良好 (r =0 91 ) ,而血药浓度与OAA/S和BIS之间较差 (r =- 0 86 ,- 0 78)。结论 BIS可以很好地监测临床镇静深度 ,但血药浓度并不能反映临床镇静深度。

Objective To study the relationship between midazolam sedation depth and its blood concentration under epidural anesthesia.Methods Ten ASA Ⅰ Ⅱ patients undergoing gynecologic surgery received epidural block and midazolam sedation.OAA/S,bispectral index (BIS) and blood concentration of midazolam were assessed during operations.The relations between them were analysed.Results Correlation coefficient between OAA/S and BIS was 0 91,but the correlations between blood concentration and OAA/S or BIS were poor ( r= -0 86,-0 78).Conclusion BIS is a good indicator of sedation depth during midazolam sedation.Blood concentration of midazolam could not reflect its clinical sedation depth.