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国外炎症性肠病治疗的现状

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摘要 过去10年中,各种5-氨基水杨酸(5-ASA)的控释、缓释、pH依赖和各种载体的制剂涌入市场,一时间成为当时的热点,近年来情况已有所改变.虽然5-ASA能抑制炎症相关因子核因子(NF)-κB的激活[1],阻断前列腺素、白三烯等炎性介质的释放,抑制中性粒细胞的趋化和清除氧自由基等,但它作为维持缓解的药物,单独使用仍有47%的复发率.其不良反应有腹泻加重、胰腺炎、肾炎和心包炎等.
作者 巫协宁
出处 《胃肠病学》 2003年第5期309-311,共3页 Chinese Journal of Gastroenterology
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