两种剂量免疫球蛋白治疗川崎病疗效探讨

A study on the treatment of Kawasaki disease with in travenous immune globulin(IVIG)in two different doses

目的:探讨不同剂量静脉滴注免疫球蛋白(IVIG)治疗小儿川崎病的疗效。方法:回顾性总结了1996～2003年收治的46例川崎病患儿治疗情况。结果:17例使用IVIG1g.kg-1,分400～500mg.kg-1.d-1*2～3d和22例IVIG2g.kg-1,分400mg.kg-1.d-1*5d治疗川崎病,在退热时间、白细胞下降至正常、冠状动脉(CA)扩张等方面无明显差异(P>0.05)。结论:IVIG治疗小儿川崎病,1g.kg-1和2g.kg-1疗效相当,推荐使用1g.kg-1IVIG,以节省资源和病人治疗费用。

Objective To explore the efficacy of two-diffe rent-dose' s IVIG whic h was used to treat Kawasaki disease.Methods To review the treatment of 46cas es ad mitted to our hospital during 1996～2003.Results46cases were di vided into two groups.One group,17cases,were treated wi th IVIG 1g-kg-1,that is,400～500mg.kg-1 .d-1* 2～3d.Another group,22cases,were t reated with IVIG 2g .kg-1 ,that is,400mg.kg-1 .d-1* 5d.There was no obvious statistical difference between the two groups(P> 0.05)in the lasting time of fever,blood white cell count,and coronary art ery dilati on(CAD),etc.Conclusion The efficacy of the two-different-dose ' s IVIG is almost equal in treatment of Kawasaki disease.We suggest that 1g. kg-1 IVIG should be used in order to save re soures and reduce patient ' s econom ic burden.