纤维蛋白原Bβ-148C/T基因多态性与心脑血栓性疾病的关系

Study of fibrinogen Bβ-148C/T gene polymorphism in patients with coronary heart disease and stroke

目的 探讨纤维蛋白原Bβ 14 8C/T基因多态性与心脑血栓性疾病的关系。 方法 采用限制性片断长度多态性分析FbgBβ 14 8C/T基因多态性频率分布 ,比浊法检测血浆Fbg水平。 结果 冠心病组和急性脑梗死组Bβ 14 8C/T基因变异频率显著高于对照组 ,伴有血浆Fbg水平的显著增高。急性脑梗死患者Bβ 14 8C/T基因变异组 (C/T及T/T)血浆Fbg水平显著高于非变异组 (C/C)。结论 FbgBβ 14

Objective To evaluate the relationship between polymorphism of fibrinogen Bβ-148C/T alleles and the etiology of coronary heart idsease(CHD).Methods Fibrinogen Bβ-148C/T alleles were analyzed by restriction fragment length polymorphism,and plasma fibrinogen levles were determined by turbidimetry.Results The variant frequencies of Bβ-148C/T alleles were significantly higher in patients with CHD and stroke,associated with an increased plasma fibrinogen levels.Plasma fibrinogen levels in stroke patients with T-148 alleles were significantly elevated than that in patients without T-148 alleles.Conclusions Fibrinogen BβT-148 alleles are associated with increasement of plasme fibrinogen level in patients with CAD and stroke,which may play an important role in the etiology of these diseases.