下肢深静脉血栓形成时血浆D-二聚体测定的临床评价

Clinical evaluation of plasma D-dimer assay in the diagnosis of deep vein thrombosis of the lower limbs

目的评估测定血浆D 二聚体 (D dimer)含量在诊断急、慢性下肢深静脉血栓形成(DVT)中的价值。方法应用胶体金免疫渗透试验 (GIA)检测 12 1例经连续多普勒超声和B 型超声证实为下肢DVT患者血浆D 二聚体的含量 (正常值≤ 0 5mg L)。 结果急性和慢性DVT组阳性检出率分别为 88 0 % (6 6 75 )和 34 8% (16 4 6 )。急性DVT组和慢性DVT组血浆D 二聚体含量分别为 (2 4± 2 2 )mg L和 (0 8± 1 3)mg L ,两组差异有显著性意义 (P <0 0 1)。 结论GIA方法准确、简单、快速、无损伤 ,可用于DVT急性期的临床诊断。

ObjectiveThe aim of this study was to evaluate the measurement of plasma D-dimer level in the diagnosis of acute and chronic deep venous thrombosis(DVT) of the lower limbs. Methods Gold colloids immunofiltration assay(GIA) was used to detect D-dimer in the plasma in 121 patients with DVT of the lower limbs confirmed by continuous wave Dopper ultrasound and B-mode ultrasound (normal value <0.5 mg/L). ResultsIn patients with acute DVT and chronic DVT, D-dimer postitive rates were 88.0%(66/75) and 34.8% (16/46) respectively. The plasma D-dimer level in patients with acute DVT and chronic DVT was(2.4±2.2 ) mg/L and( 0.8±1.3 ) mg/L respectively ( P <0.01). ConclusionsGIA assay is a rapid and simple noninvasive technique for obtaining accurate results in patients with acute DVT.