摘要
目的 前瞻性比较研究乳房切除并腋淋巴结清扫术 (MAD)与根治术 (RM )对Ⅰ、Ⅱ期乳腺癌的远期疗效。方法 将 192例Ⅰ、Ⅱ乳腺癌随机分两组 :MAD组 96例或加卵巢去势术 ;RM组 96例 ,或加卵巢去势术。MAD组腋淋巴结清除范围是腋下群淋巴结 ;RM组采用Halsted或仿根治Ⅱ式。卵巢去势是在乳房手术同时行双侧卵巢切除术。结果 MAD组和RM组 10年生存率分别为 80 4%和 81 8%;无病生存率分别为 76 7%和79 3%。局部复发率 :MAD组和RM组分别为 3 2 %和 2 3%。患侧上肢肿胀发生率 :MAD组和RM组分别为3 2 %和 7 9%。绝经前去势组 (36例 )与未去势组 (5 8例 ) 10年生存率分别为 79 4%和 81 4%,无病生存率分别为 74 7%和 74 9%。结论 对Ⅰ、Ⅱ期乳腺癌采用MAD的疗效与RM相同 ,且能改善病人的生存质量。
Objective To compare mastectomy plus axillary dissection with radical mastectomny in patients withⅠandⅡstage breast cancer. Methods One hundred and ninety-two women withⅠandⅡbreast cancer were randomly divided into two groups: one group with mastectomy and axillary dissection±ovariectomy (MAD group), another with radical mastectomy ±ovariectomy(RM group).Level-Ⅰlymph nodes in MAD group were cleared .Patients in RM group underwent Halsted radical mastectomy or modified radical mastectomy.Results Ten-year overall survival rates of MAD group and RM group were 80.4%and 81.8%, respectively.Ten-year disease-free survival rates were 76.7%and 79.3%,respectively.MAD group and RM group had the rates of 3.2%and 2.3% at local recurrence,respectively.The rates of upper limb edema was 3.2% in MAD group ,7^9% in RM group.Ten-year overall survival rates were 79.4%和81.4% in premenopausal patients with oophorectomy(36 cases) and without oophorectomy(58 cases),and 10-year disease-free survival rates were 74.7% and 74.9% in those groups,respectively.Conclusion Mastectomy plus axillary dissection has the same effect as radical mastectomy on patients with ⅠandⅡstage breast cancer. Moreover, it improves the patients’quality of life.
出处
《中国实用外科杂志》
CSCD
北大核心
2003年第10期614-616,共3页
Chinese Journal of Practical Surgery
关键词
Ⅰ期
Ⅱ期
乳腺癌
单纯乳房切除
腋淋巴结清扫
根治术
Breast neoplasm Radical mastectomy Mastectomy plus axillary dissection 10-year follow-up