β干扰素鞘内注射治疗多发性硬化的临床研究

Clinical study on interferon-β intrathecal injection in treatment of multiple sclerosis

目的 探讨 β干扰素鞘内注射治疗多发性硬化的临床效果及特点。 方法 采用随机对照研究的办法。所有入选病例均符合文献诊断标准 ,用神经功能缺损程度 (NDS)及日常生活活动量 (ADL)作为疗效评判标准。结果 研究组与对照组相比在治疗 1个疗程后、2个疗程后神经功能缺损程度及日常生活活动量评分差异均有显著意义 (P <0 0 1)。结论 β干扰素鞘内注射是治疗多发性硬化的一条有效途径 ,而且比激素治疗更有效。

Objective To investigate the effects and features of the intrathecal injection of interferon-β in treatment of multiple sclerosis(MS).Methods A randomized controlled clinical trial was carried out.All the subjects met the Baoxun Zhao's and Poser's criteria for MS.NDS and ADL were used as assessing items.Results After the first and second course of treatment,the difference of NDS and ADL between the interferon group and corticosteroids group was significant(P<0.01).Conclusion Interferon-β is an effective drug in treatment of MS and more effective than corticosteroids.