灵芝菌丝体降脂作用的实验研究

Study on the Reducing the Blood Lipids of the Ganoderma Luidum

本实验以成年雄性Wastar大鼠为研究对象,设普通饲料、高脂对照、阳性对照、灵芝四组。后三组大鼠饲喂高脂饲料,使之成为高血脂模型。然后对普通饲料组和高脂对照组饲以白水,阳性对照组饲普拉固,灵芝组饲灵芝。在饲喂前和饲喂后14、28d分别测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和胆固醇酯。结果显示:28d后阳性对照组和灵芝组的大鼠血清总胆固醇分别降低32.4%和22.5%,甘油三酯分别降低47.6%和26.3%,高密度脂蛋白胆固醇含量分别增高18.6%和22.1%,卵磷脂胆固醇酰基转移酶(LCAT)相对活性分别提高42.6%和33.1%。与高脂对照组及其自身相比,均有显著性差异(灵芝组p<0.05,阳性对照组p<0.001)。

The study was about whether ganoderma luidum reduce the blood lipid s of hyperlipid rats.The object of experiment were male Wastar rats.Then divided i nto four groups(normal diet group,hyperlipid controller group,positive controll e d group and ganoderma luidum group).Normal diet group which were fed with norm al diets.The other three groups which were all fed with hyperlipid diets and ma de them became hyperlipid animal model.Rats were fed with water in normal diet grou p and hyperlipid contrlller group,were fed with pravastain in positive cont rolle d group and were fed with ganoderma luidum in ganoderma luidum group.Total chole sterol(TC),triacylglycerol(TG),high-density-liporotein cholesterol(HDL-C)and ester cholesterol(EC) were measured in 14th and 28th day for all four g roups . The results showed that ganoderma luidum can not only reduce TC and TG v alue in hyperlipid rats significantly (p< 0.05) but also improved HDL-C and le cithin-c holesterol acyltransferase(LCAT)relative significantly(p< 0.001).