补骨脂抗癌成分的分离与鉴定

Isolation and Characterization of Anticancer Constituents from Psoralea Corylifolia

从中药补骨脂 (Psoraleacorylifolia)种子中通过溶剂提取、硅胶柱层析、SephadexLH 2 0柱层析和制备薄层层析等方法分得 4个化合物。波谱分析 (核磁共振氢谱、碳谱和质谱 )确定它们的结构分别为补骨脂素 ( 1,psoralen)、异补骨脂素 ( 2 ,isopsoralen)、补骨脂定 ( 3 ,psoralidin)和异补骨脂查尔酮 ( 4 ,isobavachalcone)。文献报道化合物 1～

Four compounds (1～4) were extracted and isolated by repeated chromatography. Their structures were identified by spectroscopic analysis ( 1H NMR, 13 CNMR and EIMS) to be psoralen (1), isopsoralen (2), psoralidin (3) and isobavachalcone (4) respectively. Compounds 1～3 were reported to possess anticancer activities.