^(99)Tc-MDP治疗类风湿性关节炎的疗效观察

Therapeutic Effect of ^(99)Tc-MDP Observed in the Treatment of Rheumatoid arthritis

目的 探讨国产新药99Tc -MDP治疗类风湿性关节炎 (RA)的疗效和安全性。方法 用99Tc -MDP治疗 2 0 8例活动性RA ,观察治疗前后的临床表现及实验室检查指标。结果 该药总有效率为 86 .1% ,在减轻疼痛、消除肿胀、增强免疫功能等方面疗效显著 ,尤其在改善晨僵、关节功能受限和降低血沉速度等方面最为明显。结论 此药疗效明显 ,使用安全 ,无明显毒副作用 ,值得临床推广使用。

Objective To evaluate the therapeutic effect and safety of 99 Tc-MDP in the treatment of rheumatoid arthritis(RA). Methods Two hundred and eight patients with active RA have been treated using 99 Tc-MDP. The clinical manifestation and laboratory examination before and after treatment were observed. Results The total effective rate of the 99 Tc-MDP was 86.1%. The effectiveness of relieving pain, diminishing swelling, increasing immune function etc was significant. It was most effective in improving morning stiffness, limitation of articulation function and decreasing ESR. Conclusion The clinical effect of the 99 Tc- MDP is obvious. Application of the 99 Tc-MDPis safety, no significant adverse action and worth clinical using.