CD15和CEA在非小细胞性肺癌组织中的表达及其意义

The Expression of CD15 and CEA in Non-Small Cell Lung Cancer

目的 观察CD15和CEA在非小细胞性肺癌中的表达情况 ,探讨它们在肺癌的发展、转移、病理分型和预后判断中的作用。方法 应用鼠抗CD15单抗和鼠抗CEA单抗 ,SP免疫组织化学染色法 ,对 5 8例肺癌组织、10例癌旁肺组织及 10例远端肺组织进行检测。结果 5 8例肺癌组织中 39例 (6 7.2 % )CD15呈阳性表达 ,4 2例(72 .4 % )CEA呈阳性表达。 2 0例肺组织中CD15和CEA均无表达。CD15在腺癌、鳞癌中的阳性表达分别为 2 9例 (96 .7% )、10例 (35 .7% )。CEA在腺癌和鳞癌中的阳性表达分别为 30例 (10 0 % )、12例 (42 .9% )。结论 CD15和CEA在肺癌中均有较高的阳性表达率 ,尤其在腺癌。CD15及CEA与肺癌的发展、转移及预后密切相关。

Objectve To study the expression of CD15 and CEA in non-small cell lung cancer i.e., the role which plays in developing,metastasis,prognosis and the pathological type in lung cancer. Methods With immunohistochemical SP technique and DAB staining,CD15 and CEA mouse monoclonal antibodies were illustrated in 58 lung cancers,10 lung tissue specimens obtained near to cancer and 10 far from cnacer. Results Of 58 lung cancers,39(67.2%)were stained with CD15 ,and 42 (72.4%) were stained with CEA.All 20 lung tissue specimens did not show CD15 staining and CEA staining.The expression of CD15 in adnocarcinoma and squamous cell carcinoma was 96.7%,35.7% respectively.The expression of CEA in adnocarcinoma and squamous cell carcinoma was 100%,42.9% respectively. Conclusion CD15 and CEA are expressed highly in lung cancer,especially in lung adnocarcinoma.CD 15 and CEA have close relation to the developing,metastasis and prognosis of lung cancer. CD15 and CEA are a useful immunohistochemical markers for differentiation lung adnocarcinoma from lung squamous cell carcinoma.