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端粒及端粒酶在膀胱癌中的研究进展 被引量:3

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摘要 端粒是位于染色体末端的DNA片段 ,具有稳定染色体结构的功能 ,它随细胞的增殖而缩短。端粒酶是重新合成端粒DNA片段的一种核糖核酸蛋白酶 ,其活化可维持端粒的长度和功能 ,使细胞永生化或成为癌细胞。本文在对端粒和端粒酶认识的基础上综述了膀胱癌、癌旁组织中端粒酶活性的研究和脱落细胞中端粒酶活性表达在膀胱癌诊断中的研究进展以及膀胱癌的抗端粒酶治疗。
出处 《国外医学(泌尿系统分册)》 2003年第6期651-654,共4页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
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  • 1宋永胜,潘春雨,杨威,陈明,符伟军.膀胱癌癌旁组织端粒酶活性检测的临床意义[J].中华泌尿外科杂志,2002,23(6):347-348. 被引量:3
  • 2符伟军,黄君健,邵国兴,徐兵,王禾,黄翠芬.端粒酶反义RNA转染促进膀胱癌T24细胞凋亡的研究[J].中华泌尿外科杂志,2002,23(1):46-48. 被引量:4
  • 3Shay JW, Pereira-Smith OM, Wright WE. Exp Cell Res, 1991 ; 196( 1 ) : 33~ 39.
  • 4Kim NW, Piatyszek MA, Prowse KR, et al. Science, 1994; 266 (5193) :2011 ~2015.
  • 5Rahat MA,Lahat N,Gazawi H,et al. Cancer,1999;85(4):919~ 924.
  • 6Yashida K, Sugino T, Tahara H, et al. Cancer, 1997 ;79(2) : 362 ~ 369.
  • 7Yokota K, Kanda K, Inoue Y, et al. Br J Urol, 1998; 82(5) : 727 ~ 732.
  • 8Wu WJ,Liu LT, Huang CH,et al. Kaohsiung J Med Sci,2001; 17(12):602~609.
  • 9Mayfield MP, Shah T, Flannigan GM, et al. Int J Mol Med, 1998; 1 (5) :835 ~ 840.
  • 10Kavaler E, Landman J, Chang Y, et al. Cancer, 1998; 82(4) :708 ~ 714.

二级参考文献13

  • 1徐祗顺 韩邦昊 等.膀胱肿瘤脱落细胞中端粒酶活性及临床意义[J].中华泌尿外科杂志,2000,21:33-33.
  • 2Balasubramanian S,Kim KH,Ahmad N,et al.Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse[].Oncegene.1999
  • 3Holt SE,Shay JW.Role of telomerase in cellular proliferation and cancer[].Journal of Cellular Physiology.1999
  • 4Rahat MA,Lahat N,Gazawi H,et al.Telomerase activity in patients with transitional cell carcinoma: a preliminary study[].Cancer.1999
  • 5Kondo S,Kondo Y,Li G,et al.Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA[].Oncegene.1998
  • 6Parkinson EK.Do telomerase antagonists represent a novel anticancer strategy[].British Journal of Cancer.1996
  • 7Shay JW,Bacchetti S.A survey of telomerase activity in human cancer[].European Journal of Cancer.1997
  • 8Yokoyama Y,Takahashi N,Shinohara A,et al.Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells[].Cancer Research.1998
  • 9Kim NW,Piatyszek MA,Prowse KR,et al.Specific association of human telomerase activity with immortal cells and can-cer[].Science.1994
  • 10Naka K,Yokozaki H,Yasui W,et al.Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines[].Biochemical and Biophysical Research Communications.1999

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