参麦注射液对大鼠心肌缺血再灌注心律失常的影响

Effect of Shenmai injection on arrhythmic rats with myocardial ischemia/reperfusion injury

目的 探讨参麦注射液对大鼠缺血再灌注心律失常的影响及其作用机制。方法 复制大鼠缺血再灌注模型 ,观察缺血 10 min、60 min和缺血 10 min后再灌注心律失常发生情况 ,对照组和参麦注射液组分别给与生理盐水和参麦注射液 1.5ml· kg- 1,颈静脉推注。动态 导心电图监测室性早搏 (PVB)、室性心动过速 (VT)及心室颤动与扑动 (VF)的发生率。结果 参麦注射液可明显减少缺血 10 m in和 60 m in心律失常 PVB、VT、VF的发生率 (P<0 .0 1) ;可明显减少再灌注10 min心律失常 VT(P<0 .0 5)及 VF(P<0 .0 1)的发生率。

ObjectiveTo investigate the effect and the me ch anism of Shenmai injection on arrhythmic rats with myocardial ischemia/reperfusi on injury.MethodMyocardial ischemia/reperfusion injury model o f rats,the conditions at 10 min, 60 min after ischemia and reperfusion 10 min af t er ischemia were observed.The 0.9%NaCl 1.5 ml·kg -1 and Shenmai injection w ere given in control group and Shenmai group,respectively before supervise occu rrence ratio of premature ventricular beats(PVB),ventricular tachycardia(VT),ven tricular fibrillation and flutter(VF) were supervised with electrocardiogram. ResultsShenmai injection obviously decreased the ratio of PV B、VT、VF after 10 min and 60 min ′ischemia (P<0.01) and the ratio of VT (P<0.05),VF(P<0.01) after 10 minutes′ reperfusion obviously.C on clusionShenmai injection can decrease the ratio of ischemia/reperfusio n arrhythmic rats.