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散发性帕金森病患者γ-synuclein基因的研究 被引量:2

Study on γ-synuclein gene in patients with idiopathic Parkinson’s disease
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摘要 目的 探讨 γ-synuclein基因 C2 43 G和 A3 77T多态在散发性帕金森病 (Parkinson' s dis-ease,PD)的疾病易感性中的意义。方法 采用聚合酶链反应 -限制性片段长度多态法 ,对上海汉族人中14 5例 PD患者和 184名正常人进行γ-synuclein基因 C2 43 G和 A3 77T多态分型 ,并作与 PD的遗传关联研究。结果  PD患者与正常对照间γ-synuclein基因 C2 43 G和 A3 77T多态分布的差异无显著性 ,两种多态与 PD亦无关联 (P值均大于 0 .0 5)。结论 上海地区汉族人群中γ-synuclein基因 C2 43 G和 A3 77T多态与散发性 Objective: To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of theγ-synuclein gene in a Chinese Han population of Shanghai area. Methods: Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls. Results: The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of theγ-synuclein gene between PD cases and control subjects, nor did they find any association. Conclusion: These data do not support that γ-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
出处 《中华医学遗传学杂志》 EI CAS CSCD 2003年第5期444-446,共3页 Chinese Journal of Medical Genetics
关键词 散发性帕金森病 γ-synuclein基因 PD 染色体 遗传性疾病 Diseases Genes Medical applications Patient treatment
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参考文献6

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共引文献3

同被引文献31

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