巨细胞病毒DNA的定量检测对病毒性心肌炎患儿病原学临床意义的探讨

Etiologic clinical significance of HCMV-DNA detection in viral myocardial children

目的 探讨巨细胞病毒 (HCMV)DNA定量检测对病毒性心肌炎患儿病原学的临床意义 ,分析血清中HCMV基因含量与心肌损伤程度及心功能变化的相关性。方法 应用荧光基因定量法对 43例心肌炎患儿进行血清HCMV基因定量检测。结果 心肌炎患儿血清中HCMV检出率明显高于正常组 ( χ2 =5 72 ,P <0 0 1) ,且血清中HCMV基因定量与心肌损伤程度呈正相关 (r =0 915 ,P <0 0 1)。结论 HCMV感染可能是引起心肌炎的一个重要病原 ,应引起重视。

Objective To explore the etiologic clinical significance of human cytomegalovirus(HCMV) infection in viral myocardial children, and to analyze the correlation between severity of myocardial injury, changes of heart function and the amount of HCMV-DNA. Methods The amount of HCMV-DNA in 43 patients with myocarditis was done by fluorescent DNA ration detection. Results The positivity rate of HCMV-DNA of the patients was obviously higher than that of the normal subjects (χ2=5.72, P<0.01), and there was a positive correlation between the amount of HCMV-DNA and the degree of myocardial injury(r=0.915, P<0.01). Conclusion The infection of HCMV may be an important factor for myocarditis and more attention should be paied to it clinically.