亚低温对多发伤患者血清中细胞因子的影响及临床意义

Effects of Mild Hypothermia on the Serum Cytokine Levels in Patients with Multiple Trauma and Its Clinical Significance

目的探讨亚低温对多发性创伤患者血清中肿瘤坏死因子 α(TNF α)、白细胞介素 1β(IL 1β)、白细胞介素 6 (IL 6 )、白细胞介素 10 (IL 10 )的影响及临床意义。方法采用酶联免疫吸附法 (ELISA)监测 38例多发性创伤患者在亚低温治疗期间外周血清TNF α、IL 1β、IL 6、IL 10在伤后即刻、d3 、d5、d9的动态变化 ,并以 30例常规治疗的多发性创伤患者作为对照组进行对比分析。结果亚低温治疗组患者血清TNF α、IL 1β、IL 6、IL 10浓度比常规治疗组明显降低 (P <0 .0 5 )。结论亚低温治疗能够降低多发性创伤患者血清中细胞因子浓度 。

ObjectivesTo explore the effects of mild hypothermia on serum levels of TNF α,IL 1β,IL 6 and IL 10 as well as its clinical significance.MethodsSixty eight patients with multiple trauma (MT) were included. Dynamic changes in peripheral serum levels of TNF α,IL 1β,IL 6 and IL 10 during mild hypothermia treatment on the first, third, fifth and ninth day after trauma were monitored using ELISA techniques in 38 cases. Thirty MT patients treated by routine therapy served as control group were analyzed comparatively.ResultsSerum levels of TNF α,IL 1β,IL 6 and IL 10 in MT patient treated with mild hypothermia were significantly lower than those in controls (P<0.05).ConclusionMild hypothermia treatment can decrease the serum levels of cytokines in MT patients.Therefore, it is inferred that this therapy may reduce the occurrence rate of multiple organ dysfunction syndrome(MODS) in MT patients.