复发性口疮血清NO、NOS的检测及临床意义

Nitric oxide and nitric oxide synthase in the development of recurrent aphthous ulcer

目的 :探讨复发性口疮 (RAU)血清一氧化氮 (NO)、一氧化氮合酶 (NOS)水平的变化及其在RAU发病过程中的作用 ,为RAU防治提供新的理论根据。方法 :检测 2 43例RAU患者发作期、愈合期及间歇期血清NO、NOS的水平 ,并与 5 0例健康对照者血清NO、NOS水平 ,比较。结果 :①发作期RAU血清NO、NOS水平高于健康对照组 (P <0 .0 1) ;②发作期RAU血清NO、NOS水平高于愈合期及间歇期RAU血清NO、NOS水平 (P <0 .0 1) ;③愈合期及间歇期血清NO、NOS水平与健康对照组血清NO、NOS水平无差异 (P >0 .0 5 ) )。结论 :RAU发作期NO、NOS升高参与了RAU的发病过程 。

Objective:To investigate serum nitric oxide(NO) and nitric oxide synthase (NOS) in the process of recurrent aphthous ulcer(RAU).Methods:Serum NO and NOS were measured with specific kits in 243 patients with RAU and 50 healthy controls.Results:Serum NO (μmol/L) in the heathy controls,the patient at stages of attack,healing and intermission was 73.15±12.30,118.50±18.95,82.11±10.00 and 81.26±12.15;NOS(μmol/L) 35.23±6.57,44.77±5.95,37.10±5.05 and 36.12±7.40,respectively.Conclussion:NO and NOS may play role in the development of RAU.