血清雌激素水平对抑郁症影响的临床研究

Clinical Study of Influence on Surum Levels of the Estrogen and Perimenopausal Period Depressive Syndrome.

目的:探讨雌激素水平对围绝经期抑郁症影响的关系。方法:对245例围绝经期综合征患者进行血清雌激素(E2)、卵泡刺激素(FSH)、黄体生成激素(LH)、雄激素(T)等指标测定;其中抑郁症95例,无抑郁症150例,分为2组进行比较。并予抑郁症组以雌-孕激素序贯治疗。结果:抑郁症患者雌激素水平明显低于无抑郁症患者,并有统计学意义(P<0.05)。抑郁症组经雌-孕激素治疗后,血清雌激素水平有所上升,且抑郁症状有所改善。结论:雌激素极低值水平是导致抑郁症的可能;雌激素对缓解抑郁症可提高围绝经期综合征的疗效。

Objective:To investigate the influence of estrogen levels and perimenopausal period depressive syndrome.Methods:To examine the Follicle Stimulating Hormone(FSH) 、Luteinizing Hormone(LH) 、Estradiol(E2) 、Testosterone(T) serum levels in 245 patients with Perimenopausal period women.The patients with Perimenopausal syndrome were divided into two groups.In the first group 95 patients with Perimenopausal syndrome;and the second group 150 patients without perimenopausal syndrome.Perimenopausal syndrome group were treated with estrogen-progestin.Methods:The level of serum E2 were very lower in depression syndrome group than no depression syndrome group (P < 0.01) .Self-retified depression scale(SDS) .score in the depression syndrome had significant differences btween before and after treatment (P < 0.05). Conclusion: Very lower level of estradiol can possibly lead to depressive syndrome. Estradiol alienating depression syndrome can improve the efficacy of treating perimenopausal syndrome.